Sacarens made it three consecutive wins in the Premiership with a 32-20 success over London Wasps on Saturday afternoon at Adams Park.
The league leaders are now seven points clear of second placed Northampton who were beaten at home to Leicester at the weekend. They are heavy favourites with Betfair to be crowned champions at the end of the campaign.
The Wasps remain seventh in the standings but will now struggle for a play-off spot as this latest defeat leaves them 16 points adrift of the top four.
Despite being down to ten men for a period in the opening half when Mouritz Botha was sin-binned, the visitors led at half-time 17-8.
Jackson Wray and Jamie George both crossed the line in the before the interval, while Jonah Holmes scored his first ever try for the Wasps.
After the break, Alex Goode added his name to the try-scorer sheet and George picked up his brace to help the Saracens extend their lead.
The home side also recorded two tries in the second half through Tom Howe and Carlo Festuccia but they were nothing more than consolations.
Saracans’ total was enough for them to pick up their eighth bonus point of the campaign so far. Only the Wasps have picked up more this season with 11 to their name.
The Premiership leaders are in action next weekend in the Heineken Cup where they take on Ulster on the road in the quarter-final.
Saracans have never won the premier European competition. They will be hoping to become the fifth different English club to do so to reward Betfair backers.
The London based club are second favourites with betfair.com to overcome their Irish opponents in the last eight.